Bacterial Transcription Continues to Surprise: Activation by Alarmone-Mediated σ-Factor Tethering

Mol Cell. 2021 Jan 7;81(1):8-9. doi: 10.1016/j.molcel.2020.12.031.

Abstract

Travis et al. (2020) reveal how Francisella tularensis uses stress-induced ppGpp to activate its virulent pathogenesis program by tethering an αCTD-DNA organizer (PigR) to a σ-organizing heterodimer (MglA-SspA), highlighting the remarkable diversity of transcriptional mechanisms in under-studied bacteria.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Francisella tularensis* / genetics
  • Francisella tularensis* / metabolism
  • Gene Expression Regulation, Bacterial
  • Guanosine Pentaphosphate
  • Sigma Factor / genetics
  • Virulence

Substances

  • Bacterial Proteins
  • Sigma Factor
  • Guanosine Pentaphosphate