Impact of Platelet Count in Retinopathy of Prematurity

Turk J Ophthalmol. 2020 Dec 29;50(6):351-355. doi: 10.4274/tjo.galenos.2020.01058.

Abstract

Objectives: The aim of the study was to investigate the risk factors for retinopathy of prematurity (ROP), including platelet count.

Materials and methods: This retrospective study analyzed 137 infants in 3 subgroups: no ROP; mild ROP, and severe ROP requiring laser treatment (type 1 ROP). A retrospective review of records was performed and statistical analysis of possible risk factors for ROP including platelet count was evaluated by using logistic regression.

Results: Birth weight (BW), gestational age (GA), and low platelet count in the first week after birth were significant risk factors for developing ROP (p=0.038, 0.02, and 0.004, respectively). BW, GA, ventilation, and lower platelet count were associated with progression to type 1 ROP (p=0.004; 0.027, and 0.021, respectively).

Conclusion: Lower platelet count in the first week after birth is a risk factor for ROP development in addition to the previously established factors of ventilation need, low BW, and low GA.

Keywords: Birth weight; gestational age; platelet; retinopathy of prematurity, risk factors.

MeSH terms

  • Birth Weight
  • Blood Platelets / pathology*
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Male
  • Platelet Count
  • Prognosis
  • Retinopathy of Prematurity / blood*
  • Retinopathy of Prematurity / diagnosis
  • Retrospective Studies
  • Risk Factors