Pulmonary vasculitis due to infection with Mycobacterium goodii: A case report

Elena Pfeuffer-Jovic; Jan Heyckendorf; Udo Reischl; Rainer M Bohle; Thorsten Bley; Andreas Buck; Heinrike Wilkens; Hans-Joachim Schäfers; Heinz-Jakob Langen; Matthias Held

doi:10.1016/j.ijid.2020.12.074

Pulmonary vasculitis due to infection with Mycobacterium goodii: A case report

Int J Infect Dis. 2021 Mar:104:178-180. doi: 10.1016/j.ijid.2020.12.074. Epub 2020 Dec 29.

Authors

Affiliations

¹ Department of Internal Medicine, Respiratory Medicine and Ventilatory Support, Medical Mission Hospital, Central Clinic Würzburg, Academic Teaching Hospital of the Julius Maximilian University of Würzburg, Würzburg, Germany. Electronic address: elena.pfeuffer-jovic@kwm-klinikum.de.
² German Center for Infection Research (DZIF), Borstel, Germany; University of Lübeck, Lübeck, Germany.
³ Institute of Medical Microbiology and Hygiene, University Hospital of Regensburg, Regensburg, Germany.
⁴ Department of Pathology, Saarland University, Homburg Saar, Germany.
⁵ Clinic for Radiology, Julius Maximilian University of Würzburg, Würzburg, Germany.
⁶ Clinic for Nuclear Medicine, Julius Maximilian University of Würzburg, Würzburg, Germany.
⁷ Department of Internal Medicine V, Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University, Homburg Saar, Germany.
⁸ Department of Thoracic and Cardiovascular Surgery, Saarland University, Homburg Saar, Germany.
⁹ Department of Radiology, Medical Mission Hospital, Central Clinic Würzburg, Academic Teaching Hospital of the Julius Maximilian University of Würzburg, Würzburg, Germany.
¹⁰ Department of Internal Medicine, Respiratory Medicine and Ventilatory Support, Medical Mission Hospital, Central Clinic Würzburg, Academic Teaching Hospital of the Julius Maximilian University of Würzburg, Würzburg, Germany.

PMID: 33383220
DOI: 10.1016/j.ijid.2020.12.074

Abstract

A 57-year-old Caucasian woman suffered from dyspnea on exertion. One year following a supposed pulmonary embolism event, a chronic thromboembolic vasculopathy was diagnosed and a pulmonary thromboendarterectomy was performed. However, a granulomatous pulmonary arterial vasculitis was identified upon examination. DNA of Mycobacterium goodii was detected as the most likely causative agent. Anti-inflammatory and anti-mycobacterial therapy was initiated for more than 12 months. Regular PET-CT scans revealed improvement under therapy. The last PET-CT did not show any tracer uptake following 10 months of therapy.

Keywords: Arteritis; Mycobacterium goodii; Nontuberculous Mycobacteria; Vasculitis.

Publication types

Case Reports

MeSH terms

Female
Gram-Positive Bacterial Infections / diagnostic imaging
Gram-Positive Bacterial Infections / drug therapy
Gram-Positive Bacterial Infections / microbiology*
Humans
Lung Diseases / diagnostic imaging
Lung Diseases / drug therapy
Lung Diseases / microbiology*
Middle Aged
Mycobacteriaceae / genetics
Mycobacteriaceae / isolation & purification*
Positron Emission Tomography Computed Tomography
Vasculitis / diagnostic imaging
Vasculitis / drug therapy
Vasculitis / microbiology*

Supplementary concepts

Mycolicibacterium goodii