The Taming of the Screw: the natural and artificial development of β-propeller proteins

Bram Mylemans; Arnout Rd Voet; Jeremy Rh Tame

doi:10.1016/j.sbi.2020.11.009

The Taming of the Screw: the natural and artificial development of β-propeller proteins

Curr Opin Struct Biol. 2021 Jun:68:48-54. doi: 10.1016/j.sbi.2020.11.009. Epub 2020 Dec 27.

Authors

Bram Mylemans¹, Arnout Rd Voet², Jeremy Rh Tame³

Affiliations

¹ Laboraotry for biomolecular modelling and design, KU Leuven, Celestijnenlaan 200G, 3001 Leuven, Belgium.
² Protein Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Suehiro 1-7-29, Tsurumi, Yokohama 230-0045, Japan.
³ Protein Design Laboratory, Graduate School of Medical Life Science, Yokohama City University, Suehiro 1-7-29, Tsurumi, Yokohama 230-0045, Japan. Electronic address: jtame@yokohama-cu.ac.jp.

PMID: 33373773
DOI: 10.1016/j.sbi.2020.11.009

Abstract

Many proteins are found to possess repeated structural elements, which hint at ancient evolutionary origins and ongoing evolutionary processes. β-propeller proteins are a large family of such proteins, and a popular focus of structural analysis. This review highlights recent work to understand how they arose, and how they have developed into one of the most successful of all protein folds.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bone Screws*
Models, Molecular
Proteins*

Substances

Proteins