Design, synthesis and biological evaluation of a novel N-aminoacyl derivative of amphotericin B methyl ester as an antifungal agent

Eur J Med Chem. 2021 Feb 5:211:113104. doi: 10.1016/j.ejmech.2020.113104. Epub 2020 Dec 17.

Authors

Jinhua Zhang¹, Hongjiang Xu², Yuanzhen Dong³, Minwei Chen³, You Zhang², Wenwen Shangguan¹, Wenjie Zhao², Jun Feng⁴

Affiliations

¹ School of Pharmacy, Fudan University, Shanghai, China.
² China State Institute of Pharmaceutical Industry, Shanghai, China.
³ Shanghai Duomirui Biotechnology Ltd., Shanghai, China.
⁴ China State Institute of Pharmaceutical Industry, Shanghai, China; Shanghai Duomirui Biotechnology Ltd., Shanghai, China. Electronic address: Fengjdmr@163.com.

PMID: 33360798
DOI: 10.1016/j.ejmech.2020.113104

No abstract available

Keywords: Amphotericin B; Antifungal activity; Hydrophilic oligomers; Pharmacodynamics and pharmacokinetics; Solid-phase synthesis.

MeSH terms

Amphotericin B / analogs & derivatives*
Animals
Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry*
Antifungal Agents / pharmacokinetics
Antifungal Agents / pharmacology*
Candida albicans / drug effects
Drug Design*
Erythrocytes / drug effects
Esters
HEK293 Cells
Hemolysis / drug effects
Humans
Mice
Mice, Inbred ICR
Microbial Sensitivity Tests
Molecular Structure
Sheep

Substances

Antifungal Agents
Esters
Amphotericin B