Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1

Cell Res. 2021 Apr;31(4):478-481. doi: 10.1038/s41422-020-00456-8. Epub 2020 Dec 21.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinases / deficiency
  • AMP-Activated Protein Kinases / genetics
  • AMP-Activated Protein Kinases / metabolism*
  • Animals
  • Fructose-Bisphosphate Aldolase / genetics
  • Fructose-Bisphosphate Aldolase / metabolism*
  • Gene Expression Regulation / drug effects*
  • Glucose / metabolism
  • Glucose / pharmacology*
  • HEK293 Cells
  • Humans
  • Lysosomes / metabolism
  • Mechanistic Target of Rapamycin Complex 1 / metabolism*
  • Mice
  • Mutagenesis, Site-Directed
  • Regulatory-Associated Protein of mTOR / chemistry
  • Regulatory-Associated Protein of mTOR / metabolism
  • Signal Transduction / drug effects

Substances

  • Regulatory-Associated Protein of mTOR
  • Mechanistic Target of Rapamycin Complex 1
  • AMP-Activated Protein Kinases
  • Fructose-Bisphosphate Aldolase
  • Glucose