A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma-like features and Nuclear Clusters (DGONC)

Jessica C Pickles; Kshitij Mankad; Miren Aizpurua; Simon Ml Paine; Leslie R Bridges; Fernando Carceller; Elwira Szychot; Mark Walker; Amy R Fairchild; Talisa Mistry; Olumide Ogunbiyi; Alice Rolland; Thomas J Stone; Carryl Dryden; Dilys Addy; Elisa Garimberti; Jane Chalker; Felix Sahm; David Tw Jones; Darren Hargrave; Thomas S Jacques

doi:10.1111/nan.12680

A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma-like features and Nuclear Clusters (DGONC)

Neuropathol Appl Neurobiol. 2021 Apr;47(3):464-467. doi: 10.1111/nan.12680. Epub 2021 Jan 12.

Authors

Jessica C Pickles^{1

2}, Kshitij Mankad³, Miren Aizpurua⁴, Simon Ml Paine⁵, Leslie R Bridges⁶, Fernando Carceller⁷, Elwira Szychot⁷, Mark Walker⁸, Amy R Fairchild^{1

2}, Talisa Mistry², Olumide Ogunbiyi², Alice Rolland⁹, Thomas J Stone^{1

2}, Carryl Dryden¹⁰, Dilys Addy¹⁰, Elisa Garimberti¹⁰, Jane Chalker¹⁰, Felix Sahm^{11

12

13}, David Tw Jones^{11

14}, Darren Hargrave^{1

15}, Thomas S Jacques^{1

2}

Affiliations

¹ Developmental Biology and Cancer (DBC) Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.
² Department of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
³ Department of Radiology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.
⁴ Department of Clinical, Neuropathology King's College Hospital NHS Foundation Trust, London, UK.
⁵ Queen's Medical Centre Campus, Nottingham University Hospitals NHS Trust, Nottingham, UK.
⁶ Department of Neuropathology, St George's Hospital NHS Trust, London, UK.
⁷ Children and Young People's Unit, The Royal Marsden NHS Foundation Trust, Surrey, UK.
⁸ Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
⁹ Département de Neurochirurgie, Centre Hospitalier Universitaire Montpellier, France.
¹⁰ Specialist Integrated Haematology and Malignancy Diagnostic Service-Acquired Genomics, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
¹¹ Hopp Children's Cancer Center Heidelberg (KiTZ, University Hospital Heidelberg, Heidelberg, Germany.
¹² Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
¹³ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK, German Cancer Research Center (DKFZ, Heidelberg, Germany.
¹⁴ Pediatric Glioma Research Group, German Cancer Research Center (DKFZ, Heidelberg, Germany.
¹⁵ Department of Paediatric Oncology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Abstract

In this study, we report three paediatric cases of Diffuse Glioneuronal Tumours with Oligodendroglioma-like features and Nuclear Clusters (DGONC).

Keywords: DNA methylation classification; brain tumour; glioneuronal tumour; monosomy 14; paediatric.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms / pathology*
Child
Ganglioglioma / pathology*
Humans
Male
Oligodendroglioma / pathology*

Abstract

Publication types

MeSH terms

Grants and funding