Asymptomatic COVID-19 with ambiguous test results

Tidsskr Nor Laegeforen. 2020 Dec 14;140(18). doi: 10.4045/tidsskr.20.0658. Print 2020 Dec 15.
[Article in English, Norwegian]

Abstract

Background: Testing for SARS-CoV-2 using polymerase chain reaction (PCR) and SARS-CoV-2 antibody tests is a significant part of the effort to combat the COVID-19 pandemic. Mass testing of healthy individuals raises several issues, however, and the results can be challenging to interpret.

Case presentation: A healthy 19-year-old man entered the military after two weeks of quarantine. The recruit had no respiratory symptoms or fever before, during or after his enrolment, and no history of SARS-CoV-2 exposure. At enrolment, he had a positive rapid test and a venous blood sample showed antibodies against SARS-CoV-2. PCR tests of specimens obtained from the upper respiratory tract were negative at enrolment and at week three, but were positive at week six.

Interpretation: The overall assessment of all the tests indicates a probable asymptomatic infection. This case report illustrates the challenge of interpreting screening results in asymptomatic individuals.

Publication types

  • Case Reports

MeSH terms

  • Asymptomatic Infections*
  • COVID-19 / diagnosis*
  • COVID-19 Nucleic Acid Testing*
  • COVID-19 Serological Testing*
  • Humans
  • Male
  • Military Personnel
  • Young Adult