Synthesis of Spiro 3,3'-Cyclopropyl Oxindoles Via N-Bromosuccinimide-Mediated Ring-Closing and Contraction Cascade

J Org Chem. 2021 Jan 1;86(1):1141-1151. doi: 10.1021/acs.joc.0c02610. Epub 2020 Dec 14.

Abstract

An N-bromosuccinimide-mediated cascade reaction involving the cyclization/oxygen-migration/ring-contraction process of 3-(β, β-diaryl) indolylethanol was disclosed. A variety of spiro 3,3'-cyclopropyl oxindole derivatives were efficiently synthesized in good yields under mild reaction conditions. A possible mechanism was suggested based on intermediate isolation and computational studies.

Publication types

  • Research Support, Non-U.S. Gov't