Synthesis of Ajoene Analogues by Novel Synthetic Strategies

Abstract

Ajoene is a compound found in garlic extracts exhibiting a large range of biological activity. Novel ajoene analogues have been prepared in the search of compounds with superior bioactivity. Modifications include the alteration of the sulfoxide, the central alkene and the terminal allyl groups.

Keywords: ajoene; biologic activity; disulfides; garlic; organosulfur compounds.