Recent studies have suggested that the right inferior frontal gyrus (rIFG) may be involved in pain-related empathy. To verify the role of the rIFG, we performed a functional magnetic resonance imaging (fMRI) experiment to replicate previous research and further designed a noninvasive repetitive transcranial magnetic stimulation (rTMS) experiment to probe the causal role of the rIFG in pain-related empathy processing. We assigned 74 volunteers (37 females) to three groups. Group 1 (n = 26) performed a task in which participants were required to perceive pain in others (task of pain: TP) and we used fMRI to observe the activity of the rIFG during pain-related empathy processing. Then, we applied online rTMS to the rIFG and the vertex site (as reference site) to observe the performance of Group 2 (n = 24; performing TP) and Group 3 (n = 24; performing a control task of identifying body parts; task of body: TB). fMRI experiment demonstrated stronger activation in the rIFG than in the vertex during the perception of pain in others (p < .0001, Bonferroni-corrected). rTMS experiment indicated that when the rIFG was temporarily disrupted, participants perceived pain in others significantly more slowly (p < .0001, Bonferroni-corrected) than when the vertex was disrupted. Our results provide evidence that the rIFG is involved in pain-related empathy processing, which yields insights into how the brain perceives pain in others.
Keywords: empathy; functional magnetic resonance imaging; pain; repetitive transcranial magnetic stimulation; right inferior frontal gyrus.
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.