Assessment of single isocenter linear accelerator radiosurgery for metastases and base of skull lesions

Abstract

Background: Newer technology for stereotactic radiosurgery (SRS) should be assessed for different multi-leaf collimators (MLC).

Objective: Assess plan quality of an automated, frameless, linear accelerator based (linac) planning and delivery system (HyperArc) for SRS using both standard MLC (SMLC) and high definition MLC (HDMLC) compared to a cobalt-60 based SRS system (Gamma Knife, GK).

Methods: We re-planned twenty GK Perfexion-treated SRS patients (27 lesions) for HyperArc using SMLC and HDMLC. We assessed plan quality using the following metrics: gradient index (GI), Paddick and RTOG conformity indices (CI_Paddick, CI_RTOG), volume receiving half of prescription isodose (PIV_half) and maximum dose to 0.03 cc for brainstem, optic chiasm and optic nerves, and V12Gy for brain-GTV.

Results: Linac plans had better conformity with HDMLC being most conformal. GK exhibited better GI. PIV_half demonstrated no statistically significant difference between HDMLC and GK, and SMLC was nominally worse than GK. Mean PIV_half was generally 0.85 cc larger for SMLC than HDMLC. For TV > 1.0 cc, the relative differences in CI_RTOG, GI, and PIV_half for SMLC vs. HDMLC were less than 21%. For TV less than < 1.0 cc, there were more obvious relative differences for SMLC vs. HDMLC in CI_RTOG (mean 146%, max 700%), GI (mean 49%, max 162%), and PIV_half (mean 77%, max 522%). Organ at risk doses were met in all plans.

Conclusions: New linac-based plans positively compare to GK plans overall. HDMLC should be strongly considered for treatment of lesions < 1.0 cc given the significant improvements in conformity and PIV_half over SMLC.

Keywords: Computer-assisted radiotherapy planning; Gamma knife radiosurgery; LINAC radiosurgery; Metastasis; Skull base; Stereotactic radiosurgery; Targeted radiation therapy.