The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway

Haematologica. 2020 Dec 1;105(12):2851-2854. doi: 10.3324/haematol.2019.238295.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Sickle Cell*
  • Humans
  • Interferon-alpha
  • Neutrophils*
  • Proteome
  • Signal Transduction

Substances

  • Interferon-alpha
  • Proteome

Grants and funding

Funding: We thank the patients and their families for their participation in the study and all members of the Sickle Cell Disease Center from the Robert Debré Hospital for the management of blood samples. This work was supported by a grant from l’Association Recherche et Transfusion, the Institut National de la Transfusion Sanguine, and the Laboratory of Excellence GR-Ex, reference ANR-11-LABX-0051; GR-Ex is funded by the program “Investissements d’avenir” of the French National Research Agency, reference ANR-11-IDEX-0005-02. The Orbitrap Fusion mass spectrometer was acquired with funds from the FEDER through the "Operational Programme for Competitiveness and Employment 2007-2013" and from the "Canceropole Ile de France".