Low-field benchtop NMR spectroscopy as a potential non-stationary tool for point-of-care urinary metabolite tracking in diabetic conditions

Mark Edgar; Benita C Percival; Miles Gibson; Fereshteh Jafari; Martin Grootveld

doi:10.1016/j.diabres.2020.108554

Low-field benchtop NMR spectroscopy as a potential non-stationary tool for point-of-care urinary metabolite tracking in diabetic conditions

Diabetes Res Clin Pract. 2021 Jan:171:108554. doi: 10.1016/j.diabres.2020.108554. Epub 2020 Nov 22.

Authors

Mark Edgar¹, Benita C Percival², Miles Gibson², Fereshteh Jafari², Martin Grootveld³

Affiliations

¹ Loughborough University, Epinal Way, Loughborough LE11 3TU, United Kingdom.
² Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, United Kingdom.
³ Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, United Kingdom. Electronic address: mgrootveld@dmu.ac.uk.

PMID: 33238175
DOI: 10.1016/j.diabres.2020.108554

Abstract

We describe the advantages and diagnostic/prognostic significance of low-field, near-portable benchtop NMR spectrometers for the multicomponent metabolomics analysis of targeted and untargeted urinary biomarkers (≥15) in type 2 diabetes patients. Implementation of these facilities at 'point-of-care' clinical sites may yield valuable advantages for the sequential monitoring of diabetic and prediabetic individuals.

Keywords: Biomarkers; NMR-based metabolomics; Non-stationary benchtop 60 MHz NMR analysis; Prediabetes; Type 2 diabetes.

MeSH terms

Adult
Case-Control Studies
Diabetes Mellitus, Type 2 / urine*
Female
Humans
Magnetic Resonance Spectroscopy / methods*
Male
Metabolomics / methods*
Middle Aged
Point-of-Care Systems / standards*
Prognosis