Modeling Donor Screening Strategies to Reduce the Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission via Fecal Microbiota Transplantation

Scott W Olesen; Amanda Zaman; Majdi Osman; Bharat Ramakrishna

doi:10.1093/ofid/ofaa499

Modeling Donor Screening Strategies to Reduce the Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Transmission via Fecal Microbiota Transplantation

Open Forum Infect Dis. 2020 Oct 19;7(11):ofaa499. doi: 10.1093/ofid/ofaa499. eCollection 2020 Nov.

Authors

Scott W Olesen¹, Amanda Zaman¹, Majdi Osman¹, Bharat Ramakrishna¹

Affiliation

¹ OpenBiome, Cambridge, Massachusetts, USA.

Abstract

The potential for transmission of severe acute respiratory syndrome coronavirus 2 shed in stool via fecal microbiota transplantation is not yet known, and the effectiveness of various testing strategies to prevent fecal microbiota transplantation-based transmission has also not yet been quantified. In this study, we use a mathematical model to simulate the utility of different testing strategies.

Keywords: Clostridioides difficile; SARS-CoV-2; fecal microbiota transplantation.