Increased superoxide in GCH1 mutant fibroblasts points to a dopamine-independent toxicity mechanism

Parkinsonism Relat Disord. 2021 Jan:82:10-12. doi: 10.1016/j.parkreldis.2020.11.012. Epub 2020 Nov 14.
No abstract available

Keywords: Dopa-responsive dystonia; GTP cyclohydrolase 1; Nitric oxide synthase; Parkinson's disease; Tetrahydrobiopterin.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Dopamine / metabolism*
  • Dopamine Agents / pharmacology
  • Dystonia / drug therapy
  • Dystonia / metabolism*
  • Fibroblasts / metabolism*
  • GTP Cyclohydrolase / genetics*
  • Humans
  • Middle Aged
  • Nitric Oxide Synthase / metabolism*
  • Parkinson Disease / metabolism*
  • Phenylketonurias / metabolism*

Substances

  • Dopamine Agents
  • Nitric Oxide Synthase
  • GCH1 protein, human
  • GTP Cyclohydrolase
  • Dopamine