Membrane-Induced Technique for the Management of Combined Soft Tissue and Osseous Defects

Clin Podiatr Med Surg. 2021 Jan;38(1):99-110. doi: 10.1016/j.cpm.2020.09.005. Epub 2020 Oct 29.

Abstract

The induced membrane technique is a simple, effective, and reproducible treatment method for segmental bone defects. It is a 2-stage approach that requires eventual autologous bone graft to manage the deficit. The first stage requires debridement of all nonviable tissue while preserving a healthy soft tissue envelope. A polymethylmethacrylate is implanted between the osseous segments to maintain length. The osseous defect can be stabilized internally or externally. During the second stage, a vascularized induced membrane is formed and produces multiple growth factors. The induced membrane technique is a valuable option for limb salvage in cases of segmental bone defects.

Keywords: Bone defect; Induced membrane; Masquelet technique.

Publication types

  • Review

MeSH terms

  • Autografts
  • Bone Regeneration
  • Cancellous Bone / transplantation
  • Debridement
  • Foreign-Body Reaction*
  • Fractures, Bone / surgery*
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Limb Salvage / methods
  • Membranes / growth & development*
  • Membranes / metabolism*
  • Soft Tissue Injuries / surgery*

Substances

  • Intercellular Signaling Peptides and Proteins