Eculizumab-Responsive Adult Onset Protein Losing Enteropathy, Caused by Germline CD55-Deficiency and Complicated by Aggressive Angiosarcoma

David Hagin; Dror Lahav; Tal Freund; Sivan Shamai; Eli Brazowski; Sigal Fishman; Alina Kurolap; Hagit Baris Feldman; Mordechai Shohat; Ophira Salomon

doi:10.1007/s10875-020-00910-7

Eculizumab-Responsive Adult Onset Protein Losing Enteropathy, Caused by Germline CD55-Deficiency and Complicated by Aggressive Angiosarcoma

J Clin Immunol. 2021 Feb;41(2):477-481. doi: 10.1007/s10875-020-00910-7. Epub 2020 Nov 19.

Authors

David Hagin^#¹, Dror Lahav^#², Tal Freund³, Sivan Shamai⁴, Eli Brazowski⁵, Sigal Fishman⁶, Alina Kurolap⁷, Hagit Baris Feldman⁸, Mordechai Shohat⁹, Ophira Salomon¹⁰

Affiliations

¹ Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine,, University of Tel Aviv, 6 Weizmann St, 64239, Tel Aviv, Israel. Davidha@tlvmc.gov.il.
² Internal Medicine Consultations, Internal Medicine Division, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, University of Tel Aviv, Tel Aviv, Israel.
³ Allergy and Clinical Immunology Unit, Department of Medicine, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine,, University of Tel Aviv, 6 Weizmann St, 64239, Tel Aviv, Israel.
⁴ Department of Oncology, Department of Medicine, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, University of Tel Aviv, Tel Aviv, Israel.
⁵ The Institute of Pathology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, University of Tel Aviv, Tel Aviv, Israel.
⁶ The Gastroenterology Institute, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, University of Tel Aviv, Tel Aviv, Israel.
⁷ The Genetics Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
⁸ The Genetics Institute, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
⁹ The Genomic Unit, Sheba Cancer Research Center, Sheba Medical Center, and Sackler Faculty of Medicine, University of Tel Aviv, Tel Aviv, Israel.
¹⁰ Institute of Thrombosis and Hemostasis, Sheba Medical Center, and Sackler Faculty of Medicine, University of Tel Aviv, Tel Aviv, Israel.

^# Contributed equally.

PMID: 33215321
DOI: 10.1007/s10875-020-00910-7

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adult
Antibodies, Monoclonal, Humanized / therapeutic use*
CD55 Antigens / deficiency*
CD55 Antigens / genetics*
Female
Germ Cells / drug effects*
Humans
Protein-Losing Enteropathies / drug therapy*
Protein-Losing Enteropathies / genetics*

Substances

Antibodies, Monoclonal, Humanized
CD55 Antigens
eculizumab