Early results of a low-profile stent-graft for thoracic endovascular aortic repair

PLoS One. 2020 Nov 19;15(11):e0240560. doi: 10.1371/journal.pone.0240560. eCollection 2020.

Abstract

Purpose: To assess outcomes of a low-profile thoracic stent-graft in the treatment of thoracic aortic pathologies.

Methods: A retrospective analysis of all consecutive patients with aortic thoracic pathologies treated with the RelayPro device in two university hospitals between October 2018 and July 2019.

Results: 23 patients (65% men; mean age 63.4 ± 15 years) were treated. Pathologies included aortic dissections (n = 10), 5 residual type A (22%) and 5 type B (22%), 6 degenerative aortic aneurysms (26%), 4 penetrating aortic ulcers (17%), and aortic erosion, intramural hematoma and aortic rupture (n = 1 and 4% in each case). Two cases (9%) were emergent and two urgent. Proximal landing was achieved in zones 0 (4%), 1 (4%), 2 (43%), and 3 (26%). Five grafts were frozen elephant trunk extensions. Technical success was 100% with accurate device deployment in the intended landing zone of the aortic arch in all 23 patients and with no Ia/III endoleaks and three (13%) type II endoleaks. Apposition was adequate in 96%. Two patients had post-implantation syndromes (one fever, one leukocytosis). Mean follow-up was 11.6 ± 3.7 months (range, 2-16) with no other complications, secondary interventions or conversions to open surgery. There was no 30-day mortality and no aortic-related mortality; all-cause mortality was 4% during follow-up.

Conclusion: A 3-4 French reduced profile in the current generation of stent-grafts facilitates TEVAR particularly in patients with smaller vessels access. Early safety and effectiveness outcomes are favorable, even in endpoints such as deployment accuracy and apposition which may be surrogates for longer-term clinical success and durability.

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aorta, Thoracic / pathology*
  • Aorta, Thoracic / surgery
  • Aortic Diseases / pathology
  • Aortic Diseases / surgery*
  • Blood Vessel Prosthesis Implantation / instrumentation*
  • Endoleak / epidemiology
  • Endoleak / etiology
  • Female
  • Humans
  • Middle Aged
  • Postoperative Complications / epidemiology
  • Retrospective Studies
  • Stents / adverse effects
  • Treatment Outcome

Grants and funding

No Funders. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.