Inhibition of CpG methylation improves the barrier integrity of bronchial epithelial cells in asthma

Allergy. 2021 Jun;76(6):1864-1868. doi: 10.1111/all.14667. Epub 2020 Dec 2.

Paulina Wawrzyniak^{1

2}, Krzysztof Krawczyk^{1

2

3}, Swati Acharya⁴, Ge Tan^{1

2

5}, Marcin Wawrzyniak^{1

2}, Emmanuel Karouzakis⁶, Anita Dreher^{1

2}, Bogdan Jakiela⁷, Can Altunbulakli^{1

2}, Marek Sanak⁷, Liam O'Mahony^{1

2

8}, Kari Nadeau⁴, Cezmi A Akdis^{1

2}

¹ Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Davos, Switzerland.
² Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
³ Department of Cellular Immunology, Faculty of Biology and Environmental Protection, Lodz, Poland.
⁴ Departament of Medicine, Stanford University, Stanford, CA, USA.
⁵ Functional Genomics Center Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland.
⁶ Department of Rheumatology, University Hospital of Zurich, Zurich, Switzerland.
⁷ Department of Medicine, Jagiellonian University Medical College, Krakow, Poland.
⁸ Department of Medicine and School of Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland.

No abstract available

Keywords: CpG methylation; DNA methyltransferases; asthma; tight junction.

Publication types