A program of continuous ambulatory peritoneal dialysis (CAPD)-renal transplantation was set up on less than 55 years old insulin dependent diabetics with end stage renal failure. Ten patients were included (age range: 9-45 years, mean: 35.6). All these patients had many complications: retinopathy, arteritis, ischemic heart disease, hypertension, neuropathy, cutaneous infection. One patient refused CAPD and was hemodialyzed for 8 months before grafting. Nine patients were treated for 3 to 45 months (mean: 14.8). During CAPD therapy, better control of hypertension and blood glucose levels were achieved. Five patients received a cadaver renal transplant 3 to 27 months (mean: 13.3) after starting CAPD. All these transplants are functioning 12 to 62 months after grafting (mean: 26.4). No post-operative complications can be directly related to CAPD. No vascular complications occurred during post-transplant follow-up. So, an integrated program CAPD-renal transplantation could be of value for young insulin-dependent diabetics.