Some Like It Sweet: Dendritic Cells Add Sugar to Their T(ea)

A C Kohlgruber; C I Wang; S J Elledge

doi:10.1016/j.cell.2020.10.033

Some Like It Sweet: Dendritic Cells Add Sugar to Their T(ea)

Cell. 2020 Nov 12;183(4):847-849. doi: 10.1016/j.cell.2020.10.033.

Authors

A C Kohlgruber¹, C I Wang², S J Elledge³

Affiliations

¹ Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.
² Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
³ Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: selledge@genetics.med.harvard.edu.

PMID: 33186527
DOI: 10.1016/j.cell.2020.10.033

Abstract

In this issue of Cell, Liu et al. present FucoID, a glycosyltransferase-mediated tagging platform, to biochemically label and capture antigen-specific T cells. With this technology, the authors isolate and characterize tumor-specific CD8+ and CD4+ T cells in murine tumor models. FucoID shows promise as a tool to enhance the understanding of anti-tumor immune responses.

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MeSH terms

Animals
Antigens, Neoplasm
Biotinylation
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes*
Dendritic Cells*
Mice
Sugars

Substances

Antigens, Neoplasm
Sugars