Microbial Metabolite Fortifies the Immune Firewall

Hiutung Chu

doi:10.1016/j.chom.2020.10.005

Microbial Metabolite Fortifies the Immune Firewall

Cell Host Microbe. 2020 Nov 11;28(5):631-633. doi: 10.1016/j.chom.2020.10.005.

Author

Hiutung Chu¹

Affiliation

¹ Department of Pathology, University of California San Diego, La Jolla, CA, USA; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccine, La Jolla, CA, USA; Humans and the Microbiome Program, CIFAR, Toronto, ON, Canada. Electronic address: hiuchu@ucsd.edu.

PMID: 33181074
DOI: 10.1016/j.chom.2020.10.005

Abstract

Clearance of pathogens by Kupffer cells is an important innate immune process in the liver. In this issue of Cell Host & Microbe, McDonald et al. reveal that microbial-derived D-lactate promotes Kupffer-cell-mediated killing of circulating pathogens.

Publication types

Comment

MeSH terms

Gastrointestinal Microbiome*
Humans
Infections*
Kupffer Cells
Liver