Influenza vaccination effectiveness in preventing influenza hospitalization in children, Hong Kong, winter 2019/20

Susan S Chiu; Huiying Chua; Mike Y W Kwan; Eunice L Y Chan; Joshua S C Wong; J S Malik Peiris; Benjamin J Cowling

doi:10.1016/j.vaccine.2020.10.081

Influenza vaccination effectiveness in preventing influenza hospitalization in children, Hong Kong, winter 2019/20

Vaccine. 2020 Dec 3;38(51):8078-8081. doi: 10.1016/j.vaccine.2020.10.081. Epub 2020 Nov 6.

Authors

Susan S Chiu¹, Huiying Chua², Mike Y W Kwan³, Eunice L Y Chan¹, Joshua S C Wong³, J S Malik Peiris², Benjamin J Cowling⁴

Affiliations

¹ Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital and Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
² WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.
³ Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong Special Administrative Region.
⁴ WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: bcowling@hku.hk.

PMID: 33168346
DOI: 10.1016/j.vaccine.2020.10.081

Abstract

The winter influenza season 2019/20 in Hong Kong was predominated by influenza A(H1N1)pdm09. We analysed an on-going test-negative design study consisting of 1227 children admitted for febrile acute respiratory illness from 3 November 2019 (week 45) to 21 March 2020 (week 12). We estimated influenza vaccine effectiveness of 65% (95% CI: 46 - 78) against hospitalization due to influenza A and B combined, and 74% (95% CI: 54 - 85) against hospitalization due to influenza A(H1N1)pdm09.

Keywords: Children; Hospitalization; Influenza; Vaccine effectiveness.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Child
Hong Kong / epidemiology
Hospitalization
Humans
Influenza A Virus, H1N1 Subtype*
Influenza A Virus, H3N2 Subtype
Influenza Vaccines*
Influenza, Human* / epidemiology
Influenza, Human* / prevention & control
Seasons
Vaccination

Substances

Influenza Vaccines