Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population

Zhilin Luan; Wenhua Ming; Xiaoxiao Huo; Jingwei Yu; Bing Wang; Yang Sun

doi:10.4103/psychiatry.IndianJPsychiatry_180_19

Genetic association of the human GAP43 gene with schizophrenia in a Northeast Chinese Han population

Indian J Psychiatry. 2020 Jul-Aug;62(4):413-417. doi: 10.4103/psychiatry.IndianJPsychiatry_180_19. Epub 2020 Jul 27.

Authors

Zhilin Luan¹, Wenhua Ming¹, Xiaoxiao Huo¹, Jingwei Yu², Bing Wang^{1

3}, Yang Sun⁴

Affiliations

¹ Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.
² Department of Biology, Guangdong Pharmaceutical University, Guangzhou, China.
³ Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China.
⁴ Department of Psychiatry, Dalian Seventh People's Hospital, Dalian, China.

PMID: 33165371
PMCID: PMC7597706
DOI: 10.4103/psychiatry.IndianJPsychiatry_180_19

Abstract

Background: GAP43, a membrane phosphoprotein with high expression level in the developing brains, plays an important role in higher integrative functions of the brain.

Materials and methods: To explore the association of GAP43 with schizophrenia, 11 single-nucleotide polymorphisms (SNPs) were examined in a Northeast Chinese Han sample set consisting of 741 schizophrenia patients and 1330 healthy controls.

Results: The results showed that three SNPs were associated with schizophrenia (rs2028248, rs6790048, and rs2164930). Haplotype analysis also revealed a significant association of a strong linkage disequilibrium block (rs2164930-rs11926976-rs16823991) with schizophrenia.

Conclusion: The current findings suggested that the human GAP43 gene may be a susceptibility gene for schizophrenia.

Keywords: Association; GAP 43; schizophrenia.