Metastatic Poorly Differentiated Thyroid Cancer With Heterogeneous Distribution of 18F-FDG, 68Ga-DOTATATE, and 68Ga-PSMA on PET/CT

Clin Nucl Med. 2021 Apr 1;46(4):e212-e213. doi: 10.1097/RLU.0000000000003362.

Abstract

We present a case of a 55-year-old man with a history of poorly differentiated metastatic thyroid cancer, which is rare and shows aggressive behavior. The patient had radioactive iodine-negative multiple metastasis on 18F-FDG PET/CT, therefore 68Ga-DOTATATE and 68Ga-PSMA PET/CT were performed whether an opportunity exist for DOTATATE or PSMA-directed radionuclide therapy. Different patterns of tumoral uptakes were detected on 18F-FDG, 68Ga-DOTATATE, and 68Ga-PSMA PET/CT, as a demonstration of tumor heterogeneity.

Publication types

  • Case Reports

MeSH terms

  • Edetic Acid / analogs & derivatives*
  • Fluorodeoxyglucose F18*
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Oligopeptides*
  • Organometallic Compounds*
  • Positron Emission Tomography Computed Tomography*
  • Thyroid Neoplasms / diagnostic imaging*
  • Thyroid Neoplasms / pathology*

Substances

  • Gallium Isotopes
  • Gallium Radioisotopes
  • Oligopeptides
  • Organometallic Compounds
  • gallium 68 PSMA-11
  • Fluorodeoxyglucose F18
  • Edetic Acid
  • gallium Ga 68 dotatate