Direct Assembly of Polysubstituted Naphthalenes via a Tandem Reaction of Benzynes and α-Cyano-β-methylenones

J Org Chem. 2020 Nov 6;85(21):14210-14218. doi: 10.1021/acs.joc.0c01975. Epub 2020 Oct 28.

Abstract

A mild and transition-metal-free benzannulation reaction for the construction of the naphthalene skeleton has been described. Benzynes react with α-cyano-β-alkylenones through a tandem nucleophilic addition/cyclization/aromatization process to afford polysubstituted naphthalenes in 50-94% yields.

Publication types

  • Research Support, Non-U.S. Gov't