An enzyme-free capacitive glucose sensor based on dual-network glucose-responsive hydrogel and coplanar electrode

Analyst. 2021 Jan 4;146(1):213-221. doi: 10.1039/d0an01672a.

Abstract

Glucose sensors are vital devices for blood glucose detection in the diabetes care. Different from traditional electrochemical devices based on glucose oxidase, the glucose sensor based on the glucose-responsive hydrogel is more robust owing to its enzyme-free principle. However, integrating the high sensitivity, fast response, wide measuring range and low-cost fabrication into a hydrogel sensor is still challenging. In this study, we present a physical capacitive sensor, which consists of interdigital carbon electrodes (ICEs) fabricated by a direct laser writing technology and glucose-responsive hydrogel (DexG-Con A hydrogel) built by UV curing in situ. The dielectric property of DexG-Con A hydrogel changes accordingly with the change in environmental glucose concentration. Experimental results demonstrate that in a glucose concentration range of 0-30 mM, the proposed hydrogel sensor is capable of measuring the glucose level in a repeatable and reversible manner, showing a short responsive time of less than 2 min and a high sensitivity of 8.81 pF mM-1 at a glucose range of 0-6 mM. Owing to its simple fabrication process, low-cost and high performance, the proposed glucose sensor shows great potential on batch production for continuous glucose monitoring application.

MeSH terms

  • Biosensing Techniques*
  • Blood Glucose
  • Blood Glucose Self-Monitoring
  • Electrodes
  • Glucose*
  • Hydrogels

Substances

  • Blood Glucose
  • Hydrogels
  • Glucose