Development of a mechanism of action reflective and robust potency assay for a therapeutic antibody against alpha toxin using rabbit erythrocytes

J Immunol Methods. 2021 Jan:488:112903. doi: 10.1016/j.jim.2020.112903. Epub 2020 Oct 17.
No abstract available

Keywords: Alpha toxin; Erythrocytes; Monoclonal antibody; Potency assay; Quality control; Staphylococcus aureus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Bacterial / metabolism*
  • Antibodies, Bacterial / therapeutic use
  • Antibodies, Monoclonal, Humanized / metabolism*
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Bacterial Toxins / immunology*
  • Broadly Neutralizing Antibodies / metabolism*
  • Broadly Neutralizing Antibodies / therapeutic use
  • Cytotoxicity Tests, Immunologic*
  • Erythrocytes / immunology
  • Erythrocytes / metabolism*
  • Erythrocytes / microbiology
  • Hemoglobins / metabolism
  • Hemolysin Proteins / immunology*
  • Hemolysis
  • Quality Control
  • Rabbits
  • Reproducibility of Results

Substances

  • Antibodies, Bacterial
  • Antibodies, Monoclonal, Humanized
  • Bacterial Toxins
  • Broadly Neutralizing Antibodies
  • Hemoglobins
  • Hemolysin Proteins
  • staphylococcal alpha-toxin
  • suvratoxumab