Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection

Emerg Infect Dis. 2021 Jan;27(1):327-329. doi: 10.3201/eid2701.203515. Epub 2020 Oct 13.

Abstract

We investigated the kinetics of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in 7 asymptomatic persons and 11 patients with pneumonia. The geometric mean titer of neutralizing antibodies declined from 219.4 at 2 months to 143.7 at 5 months after infection, indicating a waning antibody response.

Keywords: 2019 novel coronavirus disease; COVID-19; ELISA; SARS-CoV-2; antibodies; coronavirus; coronavirus disease; neutralizing antibodies; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; waning immunity; zoonoses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Neutralizing / blood*
  • Antibodies, Viral / blood*
  • Antibody Formation*
  • COVID-19 / immunology*
  • Humans
  • SARS-CoV-2 / immunology*

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral