Modern Radiotherapy and Risk of Cardiotoxicity

Efstratios Koutroumpakis; Nicolas L Palaskas; Steven H Lin; Jun-Ichi Abe; Zhongxing Liao; Jose Banchs; Anita Deswal; Syed Wamique Yusuf

doi:10.1159/000510573

Modern Radiotherapy and Risk of Cardiotoxicity

Chemotherapy. 2020;65(3-4):65-76. doi: 10.1159/000510573. Epub 2020 Oct 13.

Authors

Efstratios Koutroumpakis¹, Nicolas L Palaskas², Steven H Lin³, Jun-Ichi Abe², Zhongxing Liao³, Jose Banchs², Anita Deswal², Syed Wamique Yusuf⁴

Affiliations

¹ Division of Cardiovascular Medicine, University of Texas Health Science Center, Houston, Texas, USA.
² Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
³ Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
⁴ Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA, syusuf@mdanderson.org.

PMID: 33049738
DOI: 10.1159/000510573

Abstract

Despite the advancements of modern radiotherapy, radiation-induced heart disease remains a common cause of morbidity and mortality amongst cancer survivors. This review outlines the basic mechanism, clinical presentation, risk stratification, early detection, possible mitigation, and treatment of this condition.

Keywords: Cardiotoxicity; Radiation-induced heart disease; Radiotherapy.

Publication types

Review

MeSH terms

Cardiotoxicity
DNA Damage / radiation effects
Heart Diseases / diagnosis
Heart Diseases / etiology*
Humans
Neoplasms / radiotherapy*
Oxidative Stress / radiation effects
Radiation, Ionizing*
Risk Factors