Liver alcohol dehydrogenase

CRC Crit Rev Biochem. 1987;21(4):349-89.

Abstract

The article deals with the structure and function of liver alcohol dehydrogenase and reviews mainly literature published after 1979, i.e., summarizes progress made in the field since Klinman presented her review on alcohol dehydrogenases. The emphasis will be on high-resolution crystallographic data, results obtained with metal-substituted enzyme derivatives, and on the mechanism and pH dependence of the catalytic reaction.

Publication types

  • Review

MeSH terms

  • Alcohol Dehydrogenase / physiology*
  • Animals
  • Binding Sites
  • Coenzymes / metabolism
  • Crystallography
  • Enzyme Inhibitors / metabolism
  • Hydrogen-Ion Concentration
  • Isoenzymes / physiology
  • Kinetics
  • Liver / enzymology*
  • Macromolecular Substances
  • Metals / metabolism
  • Models, Chemical
  • Models, Molecular
  • NAD / metabolism
  • Protein Conformation
  • Structure-Activity Relationship

Substances

  • Coenzymes
  • Enzyme Inhibitors
  • Isoenzymes
  • Macromolecular Substances
  • Metals
  • NAD
  • Alcohol Dehydrogenase