Background: We investigated the prognostic value of the preoperative lymphocyte-to-mononuclear ratio (LMR) and platelet-to-lymphocyte ratio (PLR) in a large cohort of patients with non-small cell lung cancer (NSCLC).
Methods: Clinical-pathological data from 507 NSCLC patients at Taizhou Hospital of Zhejiang Province between 2010 and 2016 were retrospectively evaluated. X-tile software was used to assess the optimal cutoff levels for LMR and PLR. Univariate and multivariate Cox regression models were used to assess the prognostic factors.
Results: The median follow-up duration after surgical resection was 34.5 months. Patients were stratified into 2 groups by LMR (2.6 and > 2.6) and PLR (179.6 and > 179.6). Our results revealed that lower LMR (HR = 3.163 (1.821-5.493), P = 0.000), age (HR = 2.252 (1.412-3.592), P = 0.001), T stage (HR = 3.749 (2.275-6.179), P = 0.000), N stage (HR = 3.106 (1.967-4.902), P = 0.000), and cut edge (HR = 3.830 (1.077-13.618), P = 0.038) were considered to be independent indicators for overall survival (OS) of NSCLC patients. For disease-free survival (DFS), age, sex, T stage, N stage, LMR and cut edge were verified to be independent prognostic factors in patients with NSCLC.
Conclusions: In the study cohort, reduced LMR was a robust independent predictor for both OS and DFS in patients with NSCLC who underwent surgical resection.
Uvod: Ispitali smo prognostičku vrednost preoperativnog odnosa limfocita i mononuklearnih jedinjenja (LMR) i odnosa trombocita i limfocita (PLR) u velikoj grupi pacijenata sa nemikrocelularnim karcinomom pluća (NSCLC).
Metode: Izvršena je retrospektivna evaluacija 507 NSCLC pacijenata u Taizhou bolnici u provinciji Zhejiang između 2010. i 2016. godine. Korišćen je X-tile softver za procenu optimalnih graničnih nivoa za LMR i PLR. Za procenu prognostičkih faktora korišćeni su univarijatni i multivarijatni Cox regresioni modeli.
Rezultati: Srednje vreme praćenja nakon hirurške resekcije bilo je 34,5 meseci. Pacijenti su stratifikovani u 2 grupe u zavisnosti od LMR (2,6 i > 2,6) i PLR (179,6 i > 179,6). Naši rezultati su pokazali da su niži LMR (HR = 3,163 (1,821-5,493), P = 0,000), starost (HR = 2,252 (1,412-3,592), P = 0,001), T stadijum (HR = 3,749 (2,275-6.179), P = 0,000), N faza (HR = 3,106 (1,967-4,902), P = 0,000), i granične vrednost (HR = 3,830 (1,077-13,618), P = 0,038) smatrani nezavisnim pokazateljima ukupne stope preživljavanja (OS) pacijenata sa NSCLC. Za preživljavanje bez bolesti (DFS), starost, pol, T stadijum, N faza, LMR i cut-off vrednost su potvrđeni kao nezavisni prognostički faktori kod pacijenata sa NSCLC.
Zaključak: U kohorti studije redukovani LMR je bio robustan nezavisni prediktor i za OS i za DFS kod pacijenata sa NSCLC koji su bili podvrgnuti hirurškoj resekciji.
Keywords: lymphocyte/monocyte; non-small cell lung cancer; platelet count/lymphocyte; prognosis overall survival - disease-free survival.
2020 Haixi Yan, Linling Cai, Shuaishuai Chen, Jun Li, published by CEON/CEES.