Personal PM2.5 exposure and lung function: Potential mediating role of systematic inflammation and oxidative damage in urban adults from the general population

Abstract

Background: Short-term effects of fine particulate matter (PM_2.5) exposure on lung function have been reported. However, few studies have assessed PM_2.5 exposure on the personal level, and the mechanism underlying the effects of PM_2.5 exposure on lung function remains less clear.

Objectives: To evaluate the association between personal PM_2.5 exposure and lung function alteration in general population and to explore the roles of systematic inflammation and oxidative damage in this association.

Methods: A total of 7685 lung function tests were completed among 4697 urban adults in Wuhan, China. Plasma C-reactive protein (CRP), urinary 8-iso-prostaglandin-F_2α (8-iso-PGF_2α) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels were measured. Personal PM_2.5 exposure levels were estimated using an estimation model from the actual measurements of individual PM_2.5 levels in 191 participants. Mixed linear models were used to evaluate the association between personal PM_2.5 exposure and lung function. Mediation analyses were conducted to investigate the roles of CRP, 8-iso-PGF_2α and 8-OHdG in above associations.

Results: After adjusting for confounders, each 10 μg/m³ increase in the previous-day personal PM_2.5 exposure was associated with 2.94 mL, 2.02 mL and 16.14 mL/s decreases in forced vital capacity (FVC), forced expiration volume in 1 s (FEV₁) and peak expiratory flow, respectively. The associations were more obvious among never smokers compared with current smokers. Cumulative 7-day exposure to PM_2.5 led to the strongest adverse effects on lung function. Among never smokers with high PM_2.5 exposure levels, a positive relationship was observed between personal PM_2.5 level and urinary 8-iso-PGF_2α, and 8-iso-PGF_2α meditated 4.69% and 12.30% of the association between the 7-day moving PM_2.5 concentration and FVC and FEV₁, respectively. We did not observe a significant positive association between PM_2.5 exposure and plasma CRP or urinary 8-OHdG.

Conclusion: Short-term personal exposure to PM_2.5 is associated with reduced pulmonary ventilation function. Urinary 8-iso-PGF_2α partly mediates these associations.

Keywords: C-reactive protein; Fine particulate matter; Lung function test; Urinary 8-OHdG; Urinary 8-iso-PGF(2α).