Viral and host heterogeneity and their effects on the viral life cycle

Nat Rev Microbiol. 2021 Apr;19(4):272-282. doi: 10.1038/s41579-020-00449-9. Epub 2020 Oct 6.

Abstract

Traditionally, the viral replication cycle is envisioned as a single, well-defined loop with four major steps: attachment and entry into a target cell, replication of the viral genome, maturation of viral proteins and genome packaging into infectious progeny, and egress and dissemination to the next target cell. However, for many viruses, a growing body of evidence points towards extreme heterogeneity in each of these steps. In this Review, we reassess the major steps of the viral replication cycle by highlighting recent advances that show considerable variability during viral infection. First, we discuss heterogeneity in entry receptors, followed by a discussion on error-prone and low-fidelity polymerases and their impact on viral diversity. Next, we cover the implications of heterogeneity in genome packaging and assembly on virion morphology. Last, we explore alternative egress mechanisms, including tunnelling nanotubes and host microvesicles. In summary, we discuss the implications of viral phenotypic, morphological and genetic heterogeneity on pathogenesis and medicine. This Review highlights common themes and unique features that give nuance to the viral replication cycle.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Host-Pathogen Interactions / physiology
  • Humans
  • Receptors, Virus / metabolism
  • Viral Genome Packaging / physiology*
  • Virus Assembly / physiology
  • Virus Internalization
  • Virus Replication / physiology
  • Viruses / genetics
  • Viruses / growth & development*
  • Viruses / metabolism*

Substances

  • Receptors, Virus