Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling

Signal Transduct Target Ther. 2020 Oct 6;5(1):221. doi: 10.1038/s41392-020-00332-2.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / immunology
  • Betacoronavirus / genetics*
  • Betacoronavirus / immunology
  • Cell Line, Tumor
  • Coronavirus 3C Proteases
  • Cysteine Endopeptidases / genetics*
  • Cysteine Endopeptidases / immunology
  • Cytokines / genetics
  • Cytokines / immunology
  • DEAD Box Protein 58 / genetics
  • DEAD Box Protein 58 / immunology
  • Epithelial Cells / immunology
  • Epithelial Cells / virology
  • Gene Expression Regulation
  • Hepatocytes / immunology
  • Hepatocytes / virology
  • Host-Pathogen Interactions / genetics*
  • Host-Pathogen Interactions / immunology
  • Humans
  • Interferon Regulatory Factor-3 / genetics
  • Interferon Regulatory Factor-3 / immunology
  • Interferon-alpha / genetics*
  • Interferon-alpha / immunology
  • Interferon-beta / genetics*
  • Interferon-beta / immunology
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / immunology
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / immunology
  • Receptors, Immunologic
  • SARS-CoV-2
  • STAT1 Transcription Factor / genetics
  • STAT1 Transcription Factor / immunology
  • Signal Transduction / genetics*
  • Signal Transduction / immunology
  • Ubiquitins / genetics
  • Ubiquitins / immunology
  • Viral Nonstructural Proteins / genetics*
  • Viral Nonstructural Proteins / immunology

Substances

  • Adaptor Proteins, Signal Transducing
  • Cytokines
  • IFIT1 protein, human
  • IRF3 protein, human
  • Interferon Regulatory Factor-3
  • Interferon-alpha
  • MAVS protein, human
  • RNA-Binding Proteins
  • Receptors, Immunologic
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • Ubiquitins
  • Viral Nonstructural Proteins
  • ISG15 protein, human
  • Interferon-beta
  • Protein Serine-Threonine Kinases
  • TBK1 protein, human
  • Cysteine Endopeptidases
  • Coronavirus 3C Proteases
  • RIGI protein, human
  • DEAD Box Protein 58