Abstract
Aerodigestive adverse effects (AD-AE) during intravenous pentamidine (IV-P) infusion for Pneumocystis jiroveci pneumonia prophylaxis are uncommon in retrospective chart review studies. We conducted a survey in patients on IV-P, which included 31 specific questions. Twenty-five patients were included in the analysis; AD-AE were observed in 22 (88%) with recurrence of symptoms in 88% participants with subsequent infusions. Five leading symptoms were congestion (48%), lip tingling (32%), nausea (28%), tongue tingling (24%), vomiting, and throat swelling (17%); multiple symptoms were reported in 72% of the patients. In conclusion, AD-AE of IV-P infusion are common, self-limited, and tend to be recurrent.
Keywords:
adverse reactions; aero-digestive; children; intravenous; pentamidine.
© 2020 Wiley Periodicals LLC.
MeSH terms
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Adolescent
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Adult
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Antifungal Agents / administration & dosage
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Antifungal Agents / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Child
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Child, Preschool
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Combined Modality Therapy
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Drug-Related Side Effects and Adverse Reactions / epidemiology*
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Drug-Related Side Effects and Adverse Reactions / etiology
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Drug-Related Side Effects and Adverse Reactions / pathology
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Female
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Follow-Up Studies
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Hematopoietic Stem Cell Transplantation / adverse effects
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Humans
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Infusions, Intravenous
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Leukemia / pathology
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Leukemia / therapy*
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Male
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Michigan / epidemiology
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Pentamidine / administration & dosage
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Pentamidine / adverse effects*
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Pneumocystis carinii / drug effects*
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Pneumonia, Pneumocystis / drug therapy*
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Pneumonia, Pneumocystis / etiology
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Pneumonia, Pneumocystis / pathology
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Prognosis
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Self Report
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Surveys and Questionnaires
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Upper Gastrointestinal Tract / drug effects
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Upper Gastrointestinal Tract / pathology*
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Young Adult
Substances
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Antifungal Agents
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Pentamidine