Serum very long-chain fatty acids (VLCFA) levels as predictive biomarkers of diseases severity and probability of survival in peroxisomal disorders

PLoS One. 2020 Sep 18;15(9):e0238796. doi: 10.1371/journal.pone.0238796. eCollection 2020.

Abstract

VLCFA levels correlate with the severity of the clinical course of ZS, DBP and mild ZSD. The best predictive value for estimating the projected disease severity and survival time is a concentration of C26:0.

MeSH terms

  • Adolescent
  • Biomarkers / blood*
  • Child
  • Child, Preschool
  • Fatty Acids / blood*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Peroxisomal Disorders* / diagnosis
  • Peroxisomal Disorders* / physiopathology
  • Prognosis
  • Retrospective Studies
  • Severity of Illness Index
  • Survival Analysis
  • Young Adult
  • Zellweger Syndrome / diagnosis
  • Zellweger Syndrome / physiopathology

Substances

  • Biomarkers
  • Fatty Acids

Grants and funding

The author(s) received no specific funding for this work.