Hemorrhagic stroke associated with essential thrombocythemia: Case report and literature review

J Stroke Cerebrovasc Dis. 2020 Oct;29(10):105069. doi: 10.1016/j.jstrokecerebrovasdis.2020.105069. Epub 2020 Jul 18.

Abstract

Hemorrhagic stroke associated with essential thrombocythemia (ET) is very infrequent. Herein, we report a case of a 33-year-old woman with a 2-year history of ET who developed intracerebral and subarachnoid hemorrhage. Angiography demonstrated severe vessel irregularity in the bilateral cerebral arteries. Molecular genetic testing revealed a calreticulin mutation. To our knowledge, hemorrhagic stroke has been reported in only six other patients with ET, and this is the first report of hemorrhagic stroke in an ET patient with a calreticulin mutation. We review the current literature and discuss the possible underlying mechanisms.

Keywords: Calreticulin; Essential thrombocythemia; Hemorrhagic stroke; Vasoconstriction; Vasodilation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Calreticulin / genetics
  • Cerebral Hemorrhage / diagnostic imaging
  • Cerebral Hemorrhage / etiology*
  • Cerebral Hemorrhage / surgery
  • Craniotomy
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Mutation
  • Risk Factors
  • Stroke / diagnostic imaging
  • Stroke / etiology*
  • Subarachnoid Hemorrhage / diagnostic imaging
  • Subarachnoid Hemorrhage / etiology*
  • Subarachnoid Hemorrhage / surgery
  • Thrombocythemia, Essential / complications*
  • Thrombocythemia, Essential / diagnosis
  • Thrombocythemia, Essential / genetics
  • Treatment Outcome

Substances

  • CALR protein, human
  • Calreticulin