Silver-Catalyzed Activation of Pyridotriazoles for Formal Intramolecular Carbene Insertion into Vinylic C(sp2)-H Bonds

Org Lett. 2020 Sep 18;22(18):7255-7260. doi: 10.1021/acs.orglett.0c02586. Epub 2020 Sep 9.

Abstract

A silver-catalyzed intramolecular denitrogenative annulation of pyridotriazole with alkene was reported to achieve the challenging carbene insertion into the vinylic C(sp2)-H bond. This protocol has enabled the construction of functionalized 1H-indenes with high efficiency and excellent functional group tolerance. Experimental and computational studies suggest a stepwise mechanism involving a water-promoted hydrogen atom transfer with the aid of a silver catalyst.