Lipid peroxidation in tumour cells

Free Radic Biol Med. 1988;4(6):377-86. doi: 10.1016/0891-5849(88)90089-5.

Abstract

Several studies point to the existence of a disturbance in the metabolism of the reactive species of oxygen in cancer cells. Based on this evidence, and in particular on a characteristic behaviour of tumour membrane lipids, namely their growth-related resistance to oxy-radical-induced peroxidation, a sequence of events is outlined that could hypothetically drive the transformed cell to an uncontrolled proliferation. The proposed scheme is also conceived as a framework for further in vivo investigations of the complex biological phenomena of tumour cell growth and invasion in more integrated and kinetically controlled cellular systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Free Radicals
  • Lipid Peroxides / metabolism*
  • Neoplasms, Experimental / metabolism*
  • Tumor Cells, Cultured / metabolism*

Substances

  • Free Radicals
  • Lipid Peroxides