Resveratrol: Friend or Foe?

Thomas L Clarke; Raul Mostoslavsky

doi:10.1016/j.molcel.2020.08.008

Resveratrol: Friend or Foe?

Mol Cell. 2020 Sep 3;79(5):705-707. doi: 10.1016/j.molcel.2020.08.008.

Authors

Thomas L Clarke¹, Raul Mostoslavsky²

Affiliations

¹ The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
² The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: rmostoslavsky@mgh.harvard.edu.

PMID: 32888435
DOI: 10.1016/j.molcel.2020.08.008

Abstract

In this issue of Molecular Cell, Benslimane et al. (2020) perform a CRISPR-Cas9 chemogenomic screen, identifying a network of DNA replication and genome integrity genes with the nutraceutical compound Resveratrol and its analog Pterostilbene, linking these compounds to the induction of DNA replication stress in mammalian cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Animals
Clustered Regularly Interspaced Short Palindromic Repeats
DNA Replication*
Humans
Resveratrol*

Substances

Resveratrol

Abstract

Publication types

MeSH terms

Substances

Grants and funding