Are Organoids Ready for Prime Time?

Aparna Bhaduri; Madeline G Andrews; Arnold R Kriegstein; Tomasz J Nowakowski

doi:10.1016/j.stem.2020.08.013

Are Organoids Ready for Prime Time?

Cell Stem Cell. 2020 Sep 3;27(3):361-365. doi: 10.1016/j.stem.2020.08.013.

Authors

Aparna Bhaduri¹, Madeline G Andrews¹, Arnold R Kriegstein², Tomasz J Nowakowski³

Affiliations

¹ Department of Neurology, University of California, San Francisco, CA, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.
² Department of Neurology, University of California, San Francisco, CA, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA. Electronic address: arnold.kriegstein@ucsf.edu.
³ Department of Anatomy, University of California, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Electronic address: tomasz.nowakowski@ucsf.edu.

Abstract

Innovations in organoid-based models of human tissues have made them an exciting experimental platform for studying development and disease. However, these models require systematic benchmarking against primary tissue to establish their value. We discuss key parameters that impact the utility of organoid models, primarily focusing on cerebral organoids as examples.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Humans
Organoids*

Grants and funding

R35 NS097305/NS/NINDS NIH HHS/United States