Abstract
Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this virus. We have analysed genome sequences of SARS-CoV-2 isolated from Indian patients to gain an in-depth understanding of genomic evolution and transmission in India. Phylogenetic analysis and mutation profiling revealed major lineages being evolved by characteristic mutations. As the mutation frequency in spike protein is comparatively lesser, the candidate vaccines expected to have wide coverage worldwide including India.
Keywords:
COVID-19; India; evolution; severe acute respiratory syndrome coronavirus 2; transmission; vaccine.
MeSH terms
-
Animals
-
Antigens, Viral / genetics*
-
Antigens, Viral / immunology
-
Antigens, Viral / metabolism
-
Betacoronavirus / classification
-
Betacoronavirus / genetics*
-
Betacoronavirus / immunology
-
Betacoronavirus / pathogenicity
-
COVID-19
-
COVID-19 Vaccines
-
Chiroptera / virology
-
Coronavirus Infections / epidemiology
-
Coronavirus Infections / genetics
-
Coronavirus Infections / immunology
-
Coronavirus Infections / prevention & control*
-
Coronavirus Infections / transmission
-
Disease Reservoirs / virology
-
Eutheria / virology
-
Evolution, Molecular
-
Genome, Viral*
-
Humans
-
India / epidemiology
-
Mutation
-
Pandemics / prevention & control*
-
Phylogeny
-
Pneumonia, Viral / epidemiology
-
Pneumonia, Viral / immunology
-
Pneumonia, Viral / prevention & control*
-
Pneumonia, Viral / transmission
-
SARS-CoV-2
-
Spike Glycoprotein, Coronavirus / genetics*
-
Spike Glycoprotein, Coronavirus / immunology
-
Spike Glycoprotein, Coronavirus / metabolism
-
Viral Vaccines / biosynthesis
-
Viral Vaccines / genetics*
-
Viral Vaccines / immunology
Substances
-
Antigens, Viral
-
COVID-19 Vaccines
-
Spike Glycoprotein, Coronavirus
-
Viral Vaccines
-
spike protein, SARS-CoV-2