Severe COVID-19 Is a Microvascular Disease

Circulation. 2020 Oct 27;142(17):1609-1611. doi: 10.1161/CIRCULATIONAHA.120.050354. Epub 2020 Sep 2.
No abstract available

Keywords: P-selectin; coronavirus; exocytosis; thrombosis; von Willebrand Factor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Betacoronavirus / isolation & purification
  • COVID-19
  • Coronavirus Infections / complications
  • Coronavirus Infections / pathology*
  • Coronavirus Infections / virology
  • Cytokines / metabolism
  • Endothelium / cytology
  • Endothelium / metabolism
  • Exocytosis
  • Fibrin Fibrinogen Degradation Products / metabolism
  • Humans
  • Myocardial Infarction / complications
  • Myocardial Infarction / pathology
  • P-Selectin / antagonists & inhibitors
  • P-Selectin / metabolism
  • Pandemics
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / pathology*
  • Pneumonia, Viral / virology
  • SARS-CoV-2
  • Severity of Illness Index
  • Stroke / complications
  • Stroke / pathology
  • Vascular Diseases / complications
  • Vascular Diseases / pathology*
  • von Willebrand Factor / antagonists & inhibitors
  • von Willebrand Factor / metabolism

Substances

  • Cytokines
  • Fibrin Fibrinogen Degradation Products
  • P-Selectin
  • fibrin fragment D
  • von Willebrand Factor