(Z) - Trifluoromethyl-Trisubstituted Alkenes or Isoxazolines: Divergent Pathways from the Same Allene

Org Lett. 2020 Sep 18;22(18):7208-7212. doi: 10.1021/acs.orglett.0c02546. Epub 2020 Sep 2.

Abstract

Because of a charge-dipole interaction involving nonbonding electron pairs on fluorine, protonation of trifluoromethyl allenes leads to tri- or tetrasubstituted alkenes with high (Z)-selectivity. Treatment of the same allenes with catalytic Au(I) initiates a reaction cascade that produces isoxazolines in high yield.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.