Long noncoding RNA amplified in lung cancer rewires cancer pathways

J Cell Biol. 2020 Sep 7;219(9):e202007098. doi: 10.1083/jcb.202007098.

Abstract

Athie et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201908078) identify ALAL-1, a lncRNA frequently amplified or overexpressed in lung cancer, as an oncogenic driver, capable of promoting the proliferation and altering the immunogenicity of lung cancer cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • DNA Copy Number Variations
  • Humans
  • Immune Evasion
  • Lung Neoplasms* / genetics
  • Oligopeptides
  • RNA, Long Noncoding* / genetics

Substances

  • Oligopeptides
  • RNA, Long Noncoding
  • alanyl-leucyl-alanyl-leucine