Hypoxia-induced factor-1α induces NLRP3 expression by M1 macrophages in noneosinophilic chronic rhinosinusitis with nasal polyps

Bing Zhong; Jintao Du; Feng Liu; Yafeng Liu; Shixi Liu; Jie Zhang; Ping Lin; Jiao Zhou; Jing Liu; Hsiao Hui Ong; Kai Sen Tan; Deyun Wang; Luo Ba

doi:10.1111/all.14571

Hypoxia-induced factor-1α induces NLRP3 expression by M1 macrophages in noneosinophilic chronic rhinosinusitis with nasal polyps

Allergy. 2021 Feb;76(2):582-586. doi: 10.1111/all.14571. Epub 2020 Sep 22.

Authors

Bing Zhong^{1

2}, Jintao Du¹, Feng Liu¹, Yafeng Liu¹, Shixi Liu¹, Jie Zhang¹, Ping Lin¹, Jiao Zhou³, Jing Liu², Hsiao Hui Ong², Kai Sen Tan², Deyun Wang², Luo Ba⁴

Affiliations

¹ Upper Airway Research Laboratory, Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
² Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.
³ State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
⁴ Department of Otolaryngology, People's Hospital of Tibet Autonomous Region, Lhasa, China.

PMID: 32854144
DOI: 10.1111/all.14571

No abstract available

Keywords: NOD-like receptor family; chronic rhinosinusitis with nasal polyps; hypoxia-induced factor-1α; inflammation; macrophage; pyrin domain containing 3.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Chronic Disease
Humans
Hypoxia
Macrophages
NLR Family, Pyrin Domain-Containing 3 Protein / genetics
Nasal Polyps*
Rhinitis* / etiology
Sinusitis*

Substances

NLR Family, Pyrin Domain-Containing 3 Protein