Abstract
Chest computed tomography (CT) becomes an effective tool to assist the diagnosis of coronavirus disease-19 (COVID-19). Due to the outbreak of COVID-19 worldwide, using the computed-aided diagnosis technique for COVID-19 classification based on CT images could largely alleviate the burden of clinicians. In this paper, we propose an Adaptive Feature Selection guided Deep Forest (AFS-DF) for COVID-19 classification based on chest CT images. Specifically, we first extract location-specific features from CT images. Then, in order to capture the high-level representation of these features with the relatively small-scale data, we leverage a deep forest model to learn high-level representation of the features. Moreover, we propose a feature selection method based on the trained deep forest model to reduce the redundancy of features, where the feature selection could be adaptively incorporated with the COVID-19 classification model. We evaluated our proposed AFS-DF on COVID-19 dataset with 1495 patients of COVID-19 and 1027 patients of community acquired pneumonia (CAP). The accuracy (ACC), sensitivity (SEN), specificity (SPE), AUC, precision and F1-score achieved by our method are 91.79%, 93.05%, 89.95%, 96.35%, 93.10% and 93.07%, respectively. Experimental results on the COVID-19 dataset suggest that the proposed AFS-DF achieves superior performance in COVID-19 vs. CAP classification, compared with 4 widely used machine learning methods.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Betacoronavirus*
-
COVID-19
-
COVID-19 Testing
-
Clinical Laboratory Techniques / statistics & numerical data*
-
Computational Biology
-
Coronavirus Infections / classification
-
Coronavirus Infections / diagnosis*
-
Coronavirus Infections / diagnostic imaging*
-
Databases, Factual / statistics & numerical data
-
Deep Learning
-
Humans
-
Neural Networks, Computer
-
Pandemics / classification
-
Pneumonia, Viral / classification
-
Pneumonia, Viral / diagnosis*
-
Pneumonia, Viral / diagnostic imaging*
-
Radiographic Image Interpretation, Computer-Assisted / statistics & numerical data
-
Radiography, Thoracic / statistics & numerical data
-
SARS-CoV-2
-
Tomography, X-Ray Computed / statistics & numerical data*
Grants and funding
This work was supported in part by the National Key Research and Development Program of China under Grants 2018YFC2001600 and 2018YFC2001602, in part by the National Natural Science Foundation of China under Grants 61876082, 61861130366, 61732006, 61902183, and 81871337, in part by the Royal Society-Academy of Medical Sciences Newton Advanced Fellowship under Grant NAF\R1\180371, in part by China Postdoctoral Science Foundation funded project under Grant 2019M661831, in part by Wuhan Science and technology program under Grant 2018060401011326, in part by Hubei Provincial Novel Pneumonia Emergency Science and Technology Project under Grant 2020FCA021, in part by Huazhong University of Science and Technology Novel Coronavirus Pneumonia Emergency Science and Technology Project under Grant 2020kfyXGYJ014, and in part by the Novel Coronavirus Special Research Foundation of the Shanghai Municipal Science and Technology Commission under Grant 20441900600.