Abstract
Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Coordination Complexes / chemistry*
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Coordination Complexes / pharmacology*
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Humans
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Ligands
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Photochemotherapy
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Propiophenones / chemistry*
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Ruthenium / chemistry*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Coordination Complexes
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Ligands
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Propiophenones
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Ruthenium
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avobenzone